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Suman Ghosh

Post Doctoral Research Associate

Stowers Institute for Medical Research

1000 East 50th Street.

Kansas City. MO. 64110

sgh@stowers.org · 402-617-2712 (M) · 816-926-4326 (O)


Professional Experience

Post Doctoral Research Associate (January 10 – Present): Stowers Institute for Medical Research.

  1. Characterization of SUN protein (Mps3p) in Saccharomyces cerevisiae and its role in nuclear organization such as: telomere tethering, sister chromatid cohesion, gene silencing.

  1. Systematic proteomics and lipidomics study of nuclear membrane in budding yeast.

Research Fellow (September 09 – December 09): Massachusetts General Hospital/Harvard Medical School at the Division of Infectious Diseases.

  1. Fungal-fungal interaction that cohabit in humans in different non-mammalian host systems. The killing mechanism of Candida albicans by Aspergillus fumigatus toxins.

Lecturer (December 2001 – April 2004): Himalayan Pharmacy Institute, India.

  1. Taught Natural Product Chemistry, Pharmacognosy and Pharmaceutical Analysis courses for undergraduate students.

Senior Research Fellow (November 2000 – December 2001): Department of Natural Products at National Institute of Pharmaceutical Education and Research (NIPER), India .

  1. Standardization of 10 indigenous Indian medicinal plants by characterizing major chemical components.


Education

PhD: Micro/Molecular Biology. University of Nebraska Lincoln (2004-2009).

Thesis: Physiology, Regulation, and Pathogenesis of Nitrogen Metabolism in the Opportunistic Fungal Pathogen Candida albicans.

Master: Pharmaceutical Sciences. College of Pharmaceutical Sciences. Manipal. India. (1998-2000).

Thesis: Pharmacognostical, Phytochemical, and Wound Healing Studies of Gmelina arborea (Roxb.) Leaves.

Bachelor: Pharmaceutical Sciences. Jadavpur University. Kolkata. India. (1994-1998).



Publications

  1. Ghosh S, Howe N, Volk K, Tati S, Nickerson KW, and Petro TM. Candida albicans cell wall components and farnesol stimulate the expression of both inflammatory and regulatory cytokines in the murine RAW264.7 macrophage cell line. FEMS Immunol Med Microbiol. 2010 Jul 11

  1. Ghosh S†, Navarathna DH†, Roberts DD, Cooper JT, Atkin AL, Petro TM, and Nickerson KW. Arginine induced germ tube formation in Candida albicans is essential for escape from murine macrophage cell line RAW264.7. 2009. Infection and Immunity. 1596-1605.

  1. Ghosh S, Kebaara BW, Atkin AL, and Nickerson KW. Regulation of aromatic alcohol production in Candida albicans. 2008. Appl. Environ. Microbiol. 74: 7211-18.

  1. Shirwaikar A, Ghosh S and Rao P. Effect of Gmelina arborea (Roxb.) Leaves on Wound Healing in rats. 2003. Journal of Natural Remedies. 3: 45-48.

Manuscripts in preparation/submitted

  1. Ghosh S†, Tati S†, and Nickerson KW. Aromatic alcohols induce pseudohyphae in a GCN4 dependent manner in Candida albicans.

  1. Ghosh S, Gardner JM, Friederichs JM, Smoyer CJ, Chisholm RD, Lee K, Workman JL, and Jaspersen SL. Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization.

  1. Ghosh S†, Coleman JJ†, Okoli I, and Mylonakis E.The role of Aspergillus fumigatus gliotoxin in fungal – fungal interaction.

  1. Ghosh S, Kebaara BW, Nickerson KW, and Atkin AL.Regulation of Aro80p is critical for virulence in Candida albicans.

Technical Skills

 
Molecular Biology RT-qPCR, Northern blots, RNA/DNA Isolation, Cloning, PCR, gene disruption, transformation, Plasmid Preparation and Purification, FACS
Biochemistry Protein fractionation, IP, Immunoblots/Western Blots, SDS PAGE, 2D gel electrophoresis, cAMP Assays, Chemotaxis assay
Microscopy Immunofluorescence
Microbiology Yeast, bacteria Cell Culture, microscopic analysis, microbial physiology
Immunology RAW264.7 cell line culture, Co-infection, Fluorescence analysis
Host Model systems Caenorhabditis elegans, Galleria mellonella
High Throughput screen Well-Mate
Chromatography GC-MS, HPLC, HPTLC, affinity chromatography
Spectroscopy UV, FTIR, NMR, MS
Bioinformatics tools BLAST, Alignment, Structure and function prediction

Awards and Grants

Research Grant

Awarded Jessie Lee Scholarship Fund for research at the University of Nebraska Lincoln, 2007. ($3000)

  1. The role of arginine biosynthesis in germ tube formation by Candida albicans inside macrophages: The major goal of this project was to understand the mechanism of action of arginine induced germ tube formation and its biological significance in terms of escape from macrophage.
      1. qRTPCR array of macrophage cytokines in response to Candida albicans: The aim of this project was to perform a comprehensive study of cytokine production by murine macrophages before they were killed by ingested Candida albicans.

          2. Travel Grant

          1. Awarded Adela and Harold Holck Fund for travel, special fund from The School of Biological Sciences, University of Nebraska Lincoln. 2006. ($1000)
          1. Awarded ASM Travel Grant for the 9th Candida and Candidiasis. ASM Conference in New York, 2008. ($500)

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